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Updated: Aug 4, 2026

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Reference dosimetry at the neutron capture therapy facility at Studsvik
P M Munck af Rosenschöld1, V Giusti, C P Ceberg
1Department of Radiation Physics, Lund University Hospital, Sweden. per.munck@skane.se
Accurate dosimetry for epithermal neutron beams is crucial for neutron capture therapy. This study presents and evaluates methods for reference dosimetry, achieving acceptable uncertainty for thermal neutron fluence.
Area of Science:
- Medical Physics
- Radiation Dosimetry
- Neutron Therapy
Background:
- Neutron capture therapy (NCT) relies on precise dose delivery.
- Epithermal neutron beams are utilized in NCT, requiring accurate dosimetry.
- Reference dosimetry methods for these beams need thorough evaluation.
Purpose of the Study:
- To present and evaluate reference dosimetry methods for epithermal neutron beams.
- To calibrate the epithermal neutron beam at the Studsvik NCT facility.
- To determine absorbed doses and neutron fluence with associated uncertainties.
Main Methods:
- Measurements conducted in a PMMA phantom and in air.
- Utilized ionization chambers and activation probes for calibration.
- Employed Monte Carlo methods for beam-dependent detector calibration factors.
Main Results:
- Determined photon, neutron, and total absorbed dose to PMMA with uncertainties of +/- 5.0%, +/- 25%, and +/- 5.5% (2 SD), respectively.
- Photon absorbed dose uncertainty is comparable to conventional radiotherapy.
- Thermal neutron group fluence determined with an uncertainty of +/- 2.8% (2 SD), deemed acceptable.
Conclusions:
- The presented methodology allows for the determination of absorbed doses in epithermal neutron beams.
- Current methods yield higher uncertainty for neutron absorbed dose compared to photon absorbed dose.
- The achieved uncertainty in thermal neutron fluence is suitable for dosimetry applications in epithermal neutron beams.
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