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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Secondary immune deficiencies associated with biological therapeutics
Susan J Lee1, Parekha Yedla, Arthur Kavanaugh
1Division of Rheumatology, Allergy and Immunology, Center for Innovative Therapy, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0943, USA.
Abstract:
Biological therapeutics have been utilized in the past several years for the treatment of various autoimmune, cardiovascular, and neoplastic conditions. As these agents target both pathologic and physiologic components of inflammatory and immune systems, the scientific community has been challenged to identify potential secondary immune deficiencies associated with their use. This article will focus on biological agents used for the treatment of rheumatoid arthritis, including tumor necrosis factor-a inhibitors, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4 Ig), rituximab, and interleukin-1 receptor agonist (IL-1Ra). Both clinical and in vitro studies have been done to explore the potential immunomodulatory and immunosuppressive effects of these agents.
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