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Related Experiment Videos

Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia).

M A M Sitheeque1, L P Samaranayake

  • 1Department of Oral Medicine and Periodontology, Faculty of Dentistry, University of Peradeniya, Peradeniya, Sri Lanka.

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|August 9, 2003
PubMed
Summary

Chronic hyperplastic candidosis (CHC), a white oral patch, is mainly caused by Candida albicans. Early antifungal treatment and addressing deficiencies can resolve lesions and prevent potential cancer development.

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Is the oral fungal pathogen Candida albicans a cariogen?

Oral diseases·2017

Area of Science:

  • Oral pathology
  • Mycology
  • Dermatology

Background:

  • Chronic hyperplastic candidosis (CHC), or candidal leukoplakia, presents as asymptomatic white patches on oral mucosa.
  • Candida albicans is the primary fungal pathogen, often influenced by systemic factors like immune status and nutrition.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, and immunology of CHC.
  • To discuss histopathology, the role of Candida, and molecular aspects.
  • To outline current management and future research directions for CHC.

Main Methods:

  • Literature review focusing on demographic, etiopathogenic, and immunological features.
  • Analysis of histopathological findings and the role of Candida species.
  • Examination of molecular biology and current treatment strategies.

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Main Results:

  • CHC lesions are typically symptomless and linked to Candida albicans.
  • Untreated lesions carry a risk of dysplasia and malignant transformation.
  • Antifungal therapy and correction of deficiencies are key to resolution.

Conclusions:

  • CHC requires prompt diagnosis and management to prevent progression.
  • Understanding molecular aspects may lead to improved diagnostic and therapeutic approaches.
  • Further research is needed to fully elucidate CHC pathogenesis and optimize treatment.