Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural dynamics of eukaryotic chromosome evolution.

Evan E Eichler1, David Sankoff

  • 1Department of Genetics, Center for Human Genetics and Center for Computational Genomics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. eee@po.cwru.edu

Science (New York, N.Y.)
|August 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Legume genome structures and histories inferred from Cercis canadensis and Chamaecrista fasciculata genomes.

The Plant journal : for cell and molecular biology·2026
Same author

Branching-Process Modeling of Homology Distribution in Salmonid Genomes.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same author

The genome and population genomics of allopolyploid Coffea arabica reveal the diversification history of modern coffee cultivars.

Nature genetics·2024
Same author

Capacity, Collision Avoidance and Shopping Rate under a Social Distancing Regime.

Entropy (Basel, Switzerland)·2023
Same author

From comparative gene content and gene order to ancestral contigs, chromosomes and karyotypes.

Scientific reports·2023
Same author

Escape from Parsimony of a Double-Cut-and-Join Genome Evolution Process.

Journal of computational biology : a journal of computational molecular cell biology·2023
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Genome sequencing reveals that eukaryotic chromosome evolution involves both random rearrangements and rapid, localized changes. These hotspots of chromosomal instability drive gene family evolution and large-scale gene order alterations.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Large-scale genome sequencing offers insights into the evolutionary forces shaping eukaryotic chromosomes.
  • Comparative sequence analyses highlight patterns of genomic rearrangement and rapid, localized evolution.

Purpose of the Study:

  • To identify hotspots for eukaryotic chromosome evolution.
  • To understand the role of localized chromosomal instability in gene family evolution and gene order changes.
  • To explore computational approaches for reconstructing eukaryotic chromosome history.

Main Methods:

  • Large-scale genome sequencing.
  • Comparative sequence analyses.
  • Development of computational algorithms incorporating dynamic evolutionary forces.

Related Experiment Videos

Main Results:

  • Identified patterns of random rearrangement alongside regions of rapid, localized genome evolution.
  • Detected numerous subtle rearrangements near centromeres, telomeres, duplications, and interspersed repeats, indicating evolutionary hotspots.
  • Observed localized chromosomal instability potentially influencing lineage-specific gene families and large-scale gene order changes.

Conclusions:

  • Localized chromosomal instability is a significant factor in eukaryotic chromosome evolution.
  • These dynamic forces are crucial for the evolution of gene families and genome structure.
  • Advanced computational models integrating these forces can improve the reconstruction of eukaryotic chromosome history.