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[Association between insulin resistance and pregnancy induced hypertension. Case-control study]
Gustavo Romero Gutiérrez1, José Antonio Alvarez Cisneros, Ana Lilia Ponce Ponce de León
1Instituto Mexicano del Seguro Social, Unidad de Investigación en Epidemiología Clínica, Hospital de Gineco-Pediatría No. 48 León, Guanajuato.
Objective:
To evaluate the association between insulin resistance and the pregnancy induced hypertension.
Methods:
One hundred sixty pregnant patients were studied in the third trimester: 46 patients with preeclampsia, 34 patients with gestational hypertension and 80 healthy patients (controls). Socio demographic data were collected and the body mass index was calculated as well as the insulin resistance was evaluated through the homeostasis model assessment. Three logistic regression analyses were made: First with all the patients who developed any form of pregnancy induced hypertension, the second with patients who developed gestational hypertension and the third regression with patients who developed preeclampsia.
Results:
The variables that had statistical significance (P < 0.05) were number of pregnancies, parity, familiar incomes, and body mass index. The insulin resistance did not have statistical significance in any of the logistic regression analyses.
Conclusion:
The insulin resistance assessed in the third trimester of the pregnancy did not have association with the pregnancy induced hypertension and we recommend to carry out further investigations with prospective design and assessing insulin resistance calculating the homeostasis model assessment during all the pregnancy to evaluate this possible association.