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[The identification of the immunodominant gliadin epitope]
1Institute of Pathological Chemistry, Haim Sheba Medical Center, Tel Hashomer, Israel.
Harefuah
|August 12, 2003
Abstract:
Recent efforts have piri-pointed a relevant sequence on gliadin, that may act as the immunodominant epitope in celiac disease. Independent reports from several leading laboratories identify a 33 amino acid segment spanning through residues 57-89, and excessively rich in proline and glutamine, as the putative epitope. A glutamine residue in position 65 is the site of deamidation by transglutaminase, promoting its recognition by DQ2-HLA. In addition, another gluten protein, glutenin, may be relevant to the pathogenesis in celiac disease.