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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

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Published on: November 28, 2010

Immunomodulation with antibodies: clinical application in ovarian cancer and other malignancies

Christopher F Nicodemus1, Birgit C Schultes, Brian L Hamilton

  • 1AltaRex Corp, Waltham, MA 02451, USA. cnicodemus@altarex.com

Expert Review of Vaccines
|August 12, 2003
PubMed

This review identifies the role of antibodies in the field of therapeutic cancer vaccines. Ovarian cancer is used as a model to review advances in therapeutic vaccine development with a focus on antibodies as immunomodulators and antigen mimetics, highlighting research on B43.13 and ACA125. The interaction of biological immunomodulation and chemotherapy is discussed. Requirements of antigen processing and recent advances in the field of dendritic cell biology are critical to current understanding of potent immune response induction. Future directions including use of growth factors, adjuvants and cellular therapies to enhance effects may potentiate observed effects and provide clues for application in many cancers and beyond oncology.

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