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Laser treatment of zone I prethreshold and stage 3 threshold retinopathy of prematurity
Zsuzsa Récsán1, Rita Vámos, György Salacz
1Second Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Insights
Early laser ablation for retinopathy of prematurity (ROP) in zone I may improve structural outcomes. Treatment at prethreshold severity showed a trend toward better results than threshold severity ROP.
Area of Science:
- Ophthalmology
- Neonatology
- Pediatric Medicine
Background:
- Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
- Zone I ROP is associated with a higher risk of severe visual loss.
- Laser ablation is a common treatment for ROP.
Purpose of the Study:
- To compare the structural outcomes of zone I prethreshold and stage 3 threshold retinopathy of prematurity (ROP) after laser ablation.
- To evaluate the efficacy of early intervention for ROP in zone I.
Main Methods:
- A nonrandomized observational case series included 71 eyes of 36 infants weighing less than 1,250 g at birth.
- Infants were treated for either prethreshold or threshold ROP severity.
- Structural outcomes were compared using Fisher's exact test.
Main Results:
- A favorable structural outcome was observed in 96% of the prethreshold group and 80% of the threshold group (P = .069).
- Dragging of temporal vessels, an unfavorable outcome, was significantly more frequent in the threshold group (P = .0257).
Conclusions:
- Early treatment of zone I retinopathy of prematurity may lead to better structural outcomes.
- Prompt intervention before threshold severity appears to be beneficial in preventing unfavorable structural changes.
Purpose:
To analyze the structural outcomes of zone I prethreshold and stage 3 threshold retinopathy of prematurity following laser ablation.
Patients And Methods:
This nonrandomized observational case series evaluated 71 eyes of 36 infants who weighed less than 1,250 g at birth. Infants were treated at either prethreshold or threshold severity. The structural outcomes were compared using Fisher's exact test.
Results:
The structural outcome was favorable in 96% and 80% of the prethreshold and threshold groups, respectively (P = .069). When an unfavorable outcome was defined as dragging of the temporal vessels, the difference was significant (P = .0257).
Conclusion:
Early treatment of zone I disease may result in a better structural outcome.
