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Upper gastrointestinal endoscopy in children with upper gastrointestinal bleeding
I-Fei Huang1, Tzee-Chung Wu, Ke-Sheng Wang
1Department of Pediatrics, Kaohsiung Yeterans General Hospital, Taiwan, ROC.
Insights
Upper gastrointestinal (UGI) endoscopy is effective for diagnosing and treating UGI bleeding in children. Superficial gastric mucosal lesions were the most frequent finding, and Helicobacter pylori is linked to duodenal ulcers in some cases.
Area of Science:
- Pediatric Gastroenterology
- Endoscopy
- Infectious Diseases
Background:
- Upper gastrointestinal bleeding (UGIB) is a significant concern in pediatric patients.
- Understanding the endoscopic findings and etiological factors is crucial for effective management.
Purpose of the Study:
- To evaluate clinical presentations and endoscopic features of UGIB in children.
- To determine the role of Helicobacter pylori in pediatric UGIB.
Main Methods:
- Retrospective review of 112 children with UGIB undergoing upper gastrointestinal (UGI) endoscopy.
- Exclusion of cases due to caustic agents or foreign bodies.
- Analysis of clinical manifestations, underlying diseases, endoscopic findings, and rapid urease tests for H. pylori.
Main Results:
- Hematemesis was the most common symptom (68.8%).
- Superficial gastric mucosal lesions (SGML) were the most frequent endoscopic finding (44.6%).
- Helicobacter pylori was significantly associated with primary duodenal ulcers (DU), especially in children without underlying diseases.
Conclusions:
- UGI endoscopy is a valuable diagnostic and therapeutic tool for pediatric UGIB.
- A significant proportion of children had underlying conditions or a history of acute febrile illness.
- Helicobacter pylori plays a role in a subset of pediatric UGIB, particularly those with primary DU.
Background:
The purpose of this study was to evaluate the clinical presentations and features of upper gastrointestinal (UGI) endoscopy and the role of Helicobacter pylori in children with UGI bleeding.
Methods:
A retrospective review was done of the medical records of 112 infants and children who presented with UGI bleeding. They underwent UGI endoscopy in the Taipei Veterans General Hospital, Taiwan between July 1996 and December 2000. Patients with hematemesis caused by swallowing caustic agents or foreign bodies were excluded.
Results:
There were 112 patients involved in this study. Clinical manifestations included hematemesis (77 cases, 68.8%), tarry stool (37 cases, 33%) and hematochezia (9 cases, 8%). Fifty-three patients (47.3%) had underlying diseases, including neuromuscular deficits (17), hepatobiliary disease (17), renal insufficiency (8), Henoch-Schonlein purpura (HSP) (3), and cow milk allergy (3). Another 34 patients had a preceding acute febrile illness history. The endoscopic appearances included esophageal varices (10.7%), esophagitis or esophageal ulcers (30.4%), superficial gastric mucosal lesions (SGML) (44.6%), gastric ulcers (9.8%), duodenal ulcers (DU) (15.2%), and hemorrhagic erosive duodenitis (2.7%). Eleven cases (9.8%) showed negative findings. There were 13 (11.6%) patients receiving endoscopic hemostatic therapy. The rate of positive results in rapid urease tests in the patients without underlying diseases was 54.8%, which was significantly higher than that of the patients with underlying diseases (17.1%), while Helicobacter pylori was closely related to primary DU.
Conclusions:
In children with UGI bleeding, UGI endoscopy provides an accurate diagnostic tool and also provides therapeutic intervention when needed. SGML was the most common endoscopic finding. About 30% of the infants and children with UGI bleeding had history of acute febrile illness. Half of the children had underlying diseases. Helicobacter pylori plays a role in a subgroup of children with UGI bleeding, particularly in children with primary DU.
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