Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Particle assembly and genome packaging.

M L Linial1, S W Eastman

  • 1Division of Basic Sciences A3-015, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., Seattle, WA 98109, USA. mlinial@fhcrc.org

Current Topics in Microbiology and Immunology
|August 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Foamy virus infection in primates.

Journal of medical primatology·2006
Same author

Expanded tissue targets for foamy virus replication with simian immunodeficiency virus-induced immunosuppression.

Journal of virology·2005
Same author

Foamy virus replication: implications for interaction with other retroviruses and host cellular sequences.

Developments in biologicals·2002
Same author

Identification of a conserved residue of foamy virus Gag required for intracellular capsid assembly.

Journal of virology·2001
Same author

Cell-type-specific regulation of the two foamy virus promoters.

Journal of virology·2001
Same author

Transforming ability of Gag-Myc fusion proteins correlates with Gag-Myc protein stability and transcriptional repression.

Oncogene·2001

Foamy virus (FV) assembly diverges from retroviral norms, resembling hepadnaviruses. Key FV Gag protein features and distinct genome packaging sequences highlight its unique replication strategy.

Area of Science:

  • Virology
  • Molecular Biology
  • Biochemistry

Background:

  • Foamy viruses (FVs) represent a unique retroviral genus with distinct replication mechanisms.
  • Understanding FV assembly is crucial for comprehending retroviral diversity.

Purpose of the Study:

  • To elucidate the unique viral assembly pathway of Foamy viruses.
  • To compare FV assembly mechanisms with other retroviruses and hepadnaviruses.

Main Methods:

  • Comparative analysis of viral protein domains.
  • Investigation of Gag protein processing and localization.
  • Examination of genome packaging signals.

Main Results:

  • FV Gag protein lacks typical retroviral assembly domains but shares features with hepadnaviruses, such as uncleaved structure and arginine-rich C-termini.

Related Experiment Videos

  • FV particle egress depends on envelope glycoproteins.
  • cis-acting sequences for genome incorporation in FV differ in location from other retroviruses.

    • Conclusions:

    • Foamy virus assembly is significantly different from other retroviruses and shares similarities with hepadnaviruses.
    • The unique features of FV Gag and genome packaging contribute to its distinct replication strategy.