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Related Experiment Videos

Capacitative calcium entry in the nervous system.

James W Putney1

  • 1National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. putney@niehs.nih.gov

Cell Calcium
|August 12, 2003
PubMed
Summary
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Capacitative calcium entry, a key calcium influx pathway, is increasingly recognized for its role in neuronal function. Research is exploring its involvement in neuropathological conditions and identifying the specific channels and activation mechanisms.

Area of Science:

  • Cellular Biology
  • Neuroscience
  • Physiology

Background:

  • Capacitative calcium entry (CCE) involves Ca(2+) influx through plasma membrane channels activated by intracellular Ca(2+) store depletion.
  • Transient Receptor Potential (TRP) channels are candidate mediators of CCE, but definitive identification and activation mechanisms remain under investigation.
  • CCE is crucial for regulated Ca(2+) influx in non-excitable cells and is emerging as significant in neuronal function.

Purpose of the Study:

  • To review recent findings on the role of capacitative calcium entry in the nervous system.
  • To discuss the identified channels and proposed mechanisms of CCE activation.
  • To explore the implications of CCE in neuropathological conditions.

Main Methods:

  • Literature review of current research on capacitative calcium entry.

Related Experiment Videos

  • Analysis of studies investigating TRP channels as CCE mediators.
  • Examination of evidence linking CCE to neuronal function and dysfunction.

    • Main Results:

    • Transient Receptor Potential (TRP) channels are leading candidates for mediating capacitative calcium entry.
    • Two main hypotheses exist for CCE activation: a diffusible signal or direct protein-protein interaction.
    • Emerging evidence highlights the importance of CCE in neuronal cells and its potential role in neuropathology.

    Conclusions:

    • Capacitative calcium entry is a critical calcium influx pathway with significant implications for neuronal health and disease.
    • Further research is needed to definitively identify CCE channels and elucidate their activation mechanisms.
    • Understanding CCE in the nervous system may offer new therapeutic targets for neuropathological conditions.