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Published on: October 17, 2014
Induced-fit movements in adenylate kinases
1Institut für Organische Chemie und Biochemie der Universität, Freiburg im Breisgau, Germany.
Abstract:
Adenylate kinases have an M(r) around 23,000 which classifies them among the smallest phosphoryl group transferring enzymes. In order to prevent phosphoryl transfer to water, i.e. hydrolysis, these enzymes undergo induced-fit motions on substrate binding and assemble/disassemble their catalytic centres during each reaction cycle. Details of these processes have been derived from several X-ray structure analyses. The disturbance of these analyses by crystal-packing effects is discussed.
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