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Acute tumor lysis syndrome in hematologic malignancies
1University of Kentucky, Division of Hematology/Oncology, Markey Cancer Center, Lexington 40536-0084.
Leukemia & Lymphoma
|November 1, 1992
Summary
Acute tumor lysis syndrome (ATLS) is a serious oncologic emergency. Awareness of risk factors and proactive prophylaxis can prevent this potentially lethal complication of cancer treatment.
Area of Science:
- Oncology
- Nephrology
- Critical Care Medicine
Background:
- Acute tumor lysis syndrome (ATLS) is a life-threatening oncologic emergency.
- It is characterized by rapid release of tumor cell contents following cancer treatment.
- ATLS can lead to severe metabolic derangements and organ dysfunction.
Purpose of the Study:
- To review the pathophysiology of ATLS.
- To outline current strategies for prevention and management.
- To emphasize the importance of early recognition and intervention.
Main Methods:
- This is a review article.
- It synthesizes existing literature on ATLS.
- Focuses on clinical and laboratory parameters for prediction and management.
Main Results:
- ATLS is a predictable complication in susceptible patients.
- Prophylaxis and early treatment are crucial for preventing severe outcomes.
- Risk stratification aids in timely intervention.
Conclusions:
- ATLS is a preventable and treatable oncologic emergency.
- Understanding pathophysiology and risk factors is key.
- Multidisciplinary approach ensures optimal patient outcomes.