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[Dysembryoplastic neuroepithelial tumors].

C Daumas-Duport1, P Varlet

  • 1Laboratoire d'Anatomie Pathologique, Hôpital Sainte-Anne, Paris.

Revue Neurologique
|August 12, 2003
PubMed
Summary

Dysembryoplastic neuroepithelial tumors (DNTs) are rare brain tumors that require accurate diagnosis to avoid unnecessary treatments. Surgical removal offers a cure for most DNT-related epilepsy.

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CT and Multimodal MR Imaging Features of Embryonal Tumors with Multilayered Rosettes in Children.

AJNR. American journal of neuroradiology·2019

Area of Science:

  • Neuro-oncology
  • Developmental neurobiology
  • Neuroradiology

Context:

  • Dysembryoplastic neuroepithelial tumors (DNTs) are congenital brain tumors with diverse histological features.
  • They often present as supratentorial cortical lesions, mimicking gliomas.
  • Accurate differentiation from gliomas is crucial for appropriate patient management and prognosis.

Purpose:

  • To outline the diagnostic criteria for DNTs.
  • To emphasize the importance of distinguishing DNTs from other brain tumors.
  • To highlight the therapeutic implications of a DNT diagnosis.

Summary:

  • DNTs are polymorphic embryonal tumors typically found in the supratentorial cortex.
  • Diagnostic hallmarks include specific seizure patterns, MRI findings (cortical location, no edema/mass effect), and stable neurological status.
  • Histological mimicry of gliomas necessitates careful differential diagnosis.

Impact:

  • Correctly diagnosing DNTs spares patients from the adverse effects of radiation and chemotherapy.
  • Early surgical resection of DNTs can effectively cure associated epilepsy.
  • Timely surgical intervention prevents complications like intratumoral hematoma or infarct.

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