Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell cycle regulation and neural differentiation.

Umberto Galderisi1, Francesco Paolo Jori, Antonio Giordano

  • 1Department of Experimental Medicine, School of Medicine, Second University of Naples, Naples, Italy.

Oncogene
|August 12, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene Expression Assay in the Management of Early Breast Cancer.

Current medicinal chemistry·2019
Same author

How to 'safely' manage delivery of a pregnant woman with congenital atrioventricular block?

Journal of cardiovascular medicine (Hagerstown, Md.)·2019
Same author

Biological Effects of Ciliary Neurotrophic Factor on hMADS Adipocytes.

Frontiers in endocrinology·2019
Same author

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up.

Frontiers in oncology·2019
Same author

Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice.

Frontiers in endocrinology·2019
Same author

Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer.

PloS one·2019
Same journal

DNA methylation-mediated silencing of STAT5A drives breast cancer metastasis via dual regulation of EMT and immunosuppressive microenvironment.

Oncogene·2026
Same journal

LncRNA IRENA promotes peripheral T-cell lymphoma progression through scaffolding ARHGEF1 and FMNL1 to modulate RHOA GTPase/MAPK signaling.

Oncogene·2026
Same journal

A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer.

Oncogene·2026
Same journal

The miR-302 family suppresses tumor growth in tongue squamous cell carcinoma by directly targeting P65.

Oncogene·2026
Same journal

MOV10 suppresses circRNA biogenesis by disrupting reverse complementary matches structure to drive hepatocarcinogenesis.

Oncogene·2026
Same journal

HSP47 is a potential dual cell target and prognostic factor in pancreatic cancer.

Oncogene·2026
See all related articles

Cell cycle regulators control differentiation in the nervous system. This review summarizes key proteins like cyclin-dependent kinases and p53 involved in neural and glial development and their role in cell cycle exit.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Mammalian cell cycle control is well-understood, but cell cycle exit mechanisms in specific lineages remain unclear.
  • The link between cell cycle exit and differentiation is cell-type dependent and not fully elucidated.
  • Nervous system cells are a key focus for studying cell cycle exit and differentiation.

Purpose of the Study:

  • To review molecular mechanisms controlling cell cycle exit and differentiation in the nervous system.
  • To summarize the roles of specific proteins in neural and glial development.
  • To explore the contribution of cell cycle regulators to nervous system tumors and tumorigenesis.

Main Methods:

  • Review of in vivo and in vitro studies on nervous system cells.

Related Experiment Videos

  • Focus on key regulatory proteins: cyclin-CDK complexes, CDK inhibitors, retinoblastoma family proteins, p53, and N-Myc.
  • Analysis of data from nervous system tumors and viral oncogenes.

    • Main Results:

    • Cyclin-CDK complexes, CDK inhibitors, p53, and N-Myc are critical for cell cycle control and differentiation in neural and glial cells.
    • Evidence suggests these regulators are crucial for normal neural and glial development.
    • Dysregulation of cell cycle regulators may contribute to nervous system tumorigenesis.

    Conclusions:

    • Specific cell cycle regulators play vital roles in controlling cell cycle exit and differentiation in the nervous system.
    • Understanding these mechanisms is crucial for comprehending normal neural development and tumorigenesis.
    • Further research is needed to fully elucidate the complex interplay between cell cycle control and differentiation.