Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Relationships between the brain and the immune system].

Robert Dantzer1, Emmanuelle E Wollman

  • 1INRA-INSERM U394, rue Camille Saint-Saëns, 33077 Bordeaux, France. robert.dantzer@bordeaux.inserm.fr

Journal De La Societe De Biologie
|August 13, 2003
PubMed
Summary

The brain and immune system communicate through a complex network. Immune signals, like cytokines, can influence brain activity, affecting host responses to infection and stress.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antagonism of β-klotho signaling by peptide 19 impairs wheel running in male mice and potentiates the cisplatin-induced decrease in wheel running.

Frontiers in pharmacology·2026
Same author

Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer.

Brain, behavior, and immunity·2026
Same author

Maternal Immune Activation Leads to Mitochondrial Dysfunction and a Social Deficit in Offspring That Is Reversed by Nicotinamide Riboside.

Nutrients·2026
Same author

Obesity, low-grade inflammation, and inflammatory response to immune challenge modulate willingness to expend effort for reward.

Brain, behavior, and immunity·2026
Same author

Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer.

bioRxiv : the preprint server for biology·2025
Same author

IV IL-1 receptor antagonist reduces pain sensitivity and enhances brain endorphin release during a standardized, experimental, acute pain challenge: A BESH clinical trial.

Brain, behavior, and immunity·2025

Area of Science:

  • Neuroimmunology
  • Psychoneuroimmunology

Context:

  • The brain's influence on the immune system is understood through stress theory.
  • Recent research reveals extensive communication networks between the central nervous system and immune system.
  • Autonomic nervous system innervates lymphoid organs, and immune cells possess neurotransmitter receptors.

Purpose:

  • To explore the bidirectional communication pathways between the brain and immune system.
  • To elucidate how immune signals regulate central nervous system functions.
  • To understand the neural and humoral mechanisms of immune-to-brain communication.

Summary:

  • The brain modulates immune activity via the autonomic nervous system and neuroendocrine pathways.
  • Immune cells communicate with the brain using neurotransmitters and neuropeptides.
  • Peripheral immune signals, primarily proinflammatory cytokines, activate brain cytokine production via humoral and neural routes.
  • This brain cytokine induction orchestrates central responses to infection, including fever and sickness behavior.

Impact:

  • Highlights the critical role of neuroimmune interactions in maintaining homeostasis.
  • Provides insights into the mechanisms underlying stress-induced immune modulation.
  • Suggests novel therapeutic targets for inflammatory and infectious diseases by modulating neuroimmune pathways.

Related Experiment Videos