[Iron chelation in antimalarial therapy]
B Pradines1, J Millet, M Henry
1L'Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Marseille, France. bruno.pradines@free.fr
Abstract:
Rapid development of significant resistance to antimalarial drugs has been a major force driving research to identify and develop new compounds. A number of iron(III)-chelating compounds designed for purposes other than treating malaria have in vitro antimalarial activity stemming from iron deprivation or toxic effects related to free radical release. Several of the iron(III) chelators have been effective in animal models of plasmodial infection. Desferrioxamine has been used successfully against both uncomplicated and severe malaria in humans. Iron-chelating agents seem to be promising therapeutic adjuvants for treatment of severe Plasmodium falciparum malaria infection.
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Extraction: Advanced Methods
Pharmaceutical Poisoning: Treatment Strategies
Malaria
Anthelminthic Agents
Antiprotozoal Agents


