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Updated: Aug 8, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Studies of hTERT gene expression in acute leukemia children]
Xihong Li1, Xiaoyang Wang, Xinxiao Li
1Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To explore the gene expression of human telomerase reverse transcriptase (hTERT) in acute leukemia (AL) children and its clinical implication.
Methods:
Expression of hTERT mRNA was detected in K562 leukemia cell line, 40 acute leukemia children (AL) and 10 healthy subjects by reverse transcriptase-polymerase chain reaction (RT-PCR).
Results:
hTERT gene was expressed in K562 cell line, acute lymphoblastic leukemia children (23/30), acute myeloid leukemia children (7/10), and healthy subject (1/10). The expression level of hTERT gene was observed in all subtypes of AL and was related to the prognosis of AL, and the patients with relative level > or = 1.0 were found to have lower complete remission (CR) rates and disease-free survival.
Conclusion:
hTERT gene expression is associated with the pathogenesis of childhood AL. It can serve as a prognostic indicator in childhood AL.
