Related Experiment Video

Updated: Jul 28, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

[Effects of NaBT and NSAIDs on colorectal adenoma-carcinoma cells]

Zhihong Zhang1, Qin Ouyang, Huatian Gan

  • 1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|August 13, 2003
PubMed
Abstract

Insights

Sodium butyrate (NaBT) and non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and NS-398 inhibit cell proliferation. Combining NaBT with NSAIDs enhances these anti-proliferative effects, suggesting a potential adjuvant therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Cell Biology

Context:

  • Adenoma cells and HT-29 cells are commonly used models for colorectal cancer research.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) and sodium butyrate (NaBT) have shown potential anti-cancer properties.

Purpose:

  • To investigate the efficacy of NaBT and two NSAIDs (aspirin and NS-398) as adjuvant therapies for reducing cancer cell proliferation.
  • To explore the underlying mechanisms of their combined anti-proliferative effects.

Summary:

  • The study utilized MTT assays to evaluate the anti-proliferative effects of NaBT, aspirin, and NS-398 on primary adenoma and HT-29 cells.
  • Both NaBT and the NSAIDs demonstrated significant inhibition of cell proliferation when used individually.
  • A synergistic enhancement of anti-proliferative effects was observed when NaBT was combined with either aspirin or NS-398.

Impact:

  • The findings suggest that combining NaBT with NSAIDs could be a promising strategy for enhancing adjuvant cancer therapy.
  • This research provides a basis for further investigation into the clinical application of butyrate and NSAID combinations in cancer treatment.

More Related Videos

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Related Concept Videos

Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.