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Updated: Sep 20, 2026

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
[Awake craniotomy and brain mapping for eloquent cortex in patients with supratentorial tumors: a preliminary report]
Krzysztof Tybor1, Piotr Komuński, Agata Ciechomska
1Kliniki Neurochirurgii AM, Zakładu Radiologii AM w łodzi.
Abstract:
Malignant brain tumours are incurable at present. Since none of the hitherto used treatment methods allows to significantly extend these patients' survival time, the basic aim is to improve their quality of life. Intraoperative brain mapping seems to be an approach enabling to minimize the risk of irreversible damages to functionally important structures of the brain. In the Department of Neurosurgery of the Medical University of Łódź awake craniotomy with stimulation of eloquent cortex was attempted from May 1999 to July 2000 in 13 patients aged 16 to 77 years. In two patients the attempt of intraoperative awakening was unsuccessful. In 8 out of the 11 awakened patients intraoperative brain mapping had a significant effect on the course of surgery (i.e. on the resection magnitude and "safe corridor"). Out of six patients with tumors situated in the neighbourhood of motor cortex--one developed a severe and permanent paresis of the upper limb. On the grounds of the literature and the authors' own experience an algorithm of awake craniotomy and intraoperative brain mapping was worked out.
Insights
Awake craniotomy with intraoperative brain mapping improved surgical outcomes for malignant brain tumors. This technique helps minimize damage to critical brain areas, enhancing patient quality of life.
Area of Science:
- Neurosurgery
- Neuro-oncology
- Neurology
Context:
- Malignant brain tumors currently lack curative treatments.
- Improving patient quality of life is a primary goal.
- Minimizing damage to critical brain structures is essential.
Purpose:
- To evaluate the efficacy of awake craniotomy with intraoperative brain mapping.
- To assess the impact of brain mapping on surgical resection and safety.
- To develop an algorithm for awake craniotomy and brain mapping.
Summary:
- 13 patients (aged 16-77) underwent awake craniotomy with eloquent cortex stimulation.
- Intraoperative brain mapping significantly influenced surgical approach in 8 of 11 awakened patients.
- One patient developed permanent paresis after tumor resection near the motor cortex.
Impact:
- Awake craniotomy with brain mapping can optimize surgical resection and preserve neurological function.
- The study provides an algorithm for performing awake craniotomy and intraoperative brain mapping.
- This approach aims to improve the quality of life for patients with malignant brain tumors.

