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Cefixime for the prophylaxis of urinary tract infections in children with malformative uropathies: an open study

G Stranieri1, S Zampogna, V Ielapi

  • 1Struttura Complessa di Chirurgia Pediatrica, Azienda Ospedaliera Pugliese Ciaccio - Catanzaro, Italy.

European Review for Medical and Pharmacological Sciences
|August 13, 2003
PubMed

Insights

Cefixime, a 3rd generation cephalosporin antibiotic, shows effectiveness in the long-term prophylaxis of urinary tract infections (UTIs) associated with urinary anomalies. This antibiotic is crucial for preventing kidney damage from pyelonephritis, especially with rising bacterial resistance.

Area of Science:

  • Urology
  • Infectious Diseases
  • Pharmacology

Background:

  • Urinary tract infections (UTIs) frequently coexist with urinary anomalies.
  • Kidney damage from pyelonephritis can be mitigated by appropriate pharmacologic treatment.
  • Antibiotic prophylaxis is as vital as early surgical intervention for UTIs, especially with trends toward less aggressive therapies.

Purpose of the Study:

  • To evaluate the effectiveness of cefixime in the long-term prophylaxis of UTIs in patients with urinary anomalies.
  • To assess cefixime's role in preventing kidney damage in the context of increasing antibiotic resistance.

Main Methods:

  • A series of patients with UTIs and associated urinary tract anomalies were treated with cefixime.
  • Cefixime, a 3rd generation cephalosporin, was administered for prophylactic treatment.

Main Results:

  • Significant positive outcomes were observed in patients receiving cefixime prophylaxis.
  • The study highlights the efficacy of cefixime in managing UTIs linked to urinary anomalies.

Conclusions:

  • Cefixime demonstrates effectiveness for long-term prophylaxis of UTIs in patients with urinary anomalies.
  • The findings support cefixime as a valuable therapeutic option, particularly given current bacterial resistance patterns.

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