Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intra-articular hyaluronan therapy.

K Wayne Marshall1

  • 1Division of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada. wmarshall@chondrogene.com

Foot and Ankle Clinics
|August 13, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synovial fluid monocyte/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study.

Arthritis research & therapy·2019
Same author

Novel blood-based, five-gene biomarker set for the detection of colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2008
Same author

Chondrocyte genomics: implications for disease modification in osteoarthritis.

Drug discovery today·2006
Same author

Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.

Atherosclerosis·2006
Same author

Novel blood biomarkers of human urinary bladder cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2006
Same author

Characterization of proteoglycan depletion in articular cartilage using two-dimensional time domain nuclear magnetic resonance.

Magnetic resonance in medicine·2005
Same journal

New Trends in Circular External Fixation of the Foot and Ankle.

Foot and ankle clinics·2026
Same journal

Common Difficulties and Complications of Circular External Fixation in the Foot and Ankle.

Foot and ankle clinics·2026
Same journal

External Fixation for the Management of Clubfoot Sequelae in Children and Adolescents.

Foot and ankle clinics·2026
Same journal

Ankle Distraction Arthroplasty: Evidence and Current Indications.

Foot and ankle clinics·2026
Same journal

Distal Third Tibial Nonunions: Understanding Its Causes and Ring Fixator Treatment Strategies.

Foot and ankle clinics·2026
Same journal

Minimally Invasive Treatment of Tibial Plafond Fractures Using Circular External Fixators.

Foot and ankle clinics·2026
See all related articles

Viscosupplementation, using hyaluronan injections, effectively treats knee osteoarthritis. This approach may also benefit foot and ankle osteoarthritis, warranting further clinical investigation.

Area of Science:

  • Orthopedics
  • Rheumatology
  • Biomedical Engineering

Background:

  • Viscosupplementation, involving intra-articular injections of hyaluronan derivatives, is a common treatment for knee osteoarthritis (OA).
  • Currently, no viscosupplements are approved for treating osteoarthritis in joints other than the knee.
  • No published clinical trials have investigated viscosupplementation for ankle or foot OA.

Purpose of the Study:

  • To explore the potential of viscosupplementation for treating foot and ankle osteoarthritis.
  • To encourage research into the efficacy of viscosupplementation beyond the knee joint.

Main Methods:

  • Literature review and theoretical application of known viscosupplementation mechanisms.
  • Analysis of the biological plausibility of using viscosupplements in synovial joints like the foot and ankle.

Related Experiment Videos

Main Results:

  • The therapeutic mechanisms of viscosupplementation are likely applicable to any synovial joint.
  • The potential benefits for foot and ankle OA remain unexplored in clinical trials.

Conclusions:

  • Viscosupplementation holds potential for treating foot and ankle osteoarthritis.
  • Further research and clinical trials are needed to validate its use in these joints.