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Anemia in pediatric hemodialysis patients: results from the 2001 ESRD Clinical Performance Measures Project
Diane L Frankenfield1, Alica M Neu, Bradley A Warady
1Center for Beneficiary Choices, Centers for Medicare & Medicaid Services, Baltimore, Maryland, USA.
Insights
Anemia affects 37% of pediatric hemodialysis patients. Key predictors include short dialysis duration, low albumin, and low transferrin saturation (TSAT).
Area of Science:
- Pediatric Nephrology
- Hematology
Background:
- Anemia remains a significant complication in children undergoing hemodialysis.
- Despite advancements in dialysis care, achieving target hemoglobin levels is challenging for this population.
Purpose of the Study:
- To investigate the contributing factors and predictors of anemia in pediatric hemodialysis patients.
- To identify clinical parameters associated with anemia in this specific demographic.
Main Methods:
- Retrospective analysis of clinical data from pediatric hemodialysis patients (ages 12-18) using Centers for Medicare and Medicaid Services data.
- Data collected between October and December 2000, with a final cohort of 435 patients.
Main Results:
- 37% of patients had anemia (hemoglobin <11 g/dL).
- Anemia was more prevalent in patients on dialysis for less than 6 months (67%).
- Anemic patients showed lower mean transferrin saturation (TSAT <20%), lower albumin levels, and lower mean Kt/V values compared to non-anemic patients.
Conclusions:
- Dialysis duration less than 6 months, low serum albumin, and low mean TSAT (<20%) are significant predictors of anemia in pediatric hemodialysis patients.
- These findings highlight the need for targeted monitoring and interventions for anemia in this vulnerable group.
Background:
Despite improvements in dialysis care, anemia remains a problem in pediatric hemodialysis patients.
Methods:
To assess possible explanations for the anemia, clinical data were obtained from the Centers for Medicare and Medicaid Services on all hemodialysis patients ages 12 to <18 years between October and December 2000. Complete data were available for 435 of the 516 patients (84%).
Results:
A total of 160 (37%) patients had a mean hemoglobin of <11 g/dL (anemic). The mean (+/- SD) age for these patients was 15.5 +/- 1.8 years compared to 15.9 +/- 1.5 years for the target hemoglobin patients (P < 0.05). Mean time on chronic dialysis was similar for both the anemic and target hemoglobin patients (>/=100 g/dL) ( approximately 3 years) but patients on dialysis <6 months were more likely to be anemic (67%). While nearly all patients were treated with erythropoietin, anemic patients received greater weekly erythropoietin doses (intravenous, anemia 374 +/- 232 units/kg/week vs. target hemoglobin 246 +/- 196 units/kg/week, P < 0.001; and subcutaneous, 304 +/- 238 units/kg/week vs. 167 +/- 99 units/kg/week, P < 0.05). A total of 59% of anemic patients had a mean transferrin saturation (TSAT) >/=20% compared to 71% of patients with a target hemoglobin (P < 0.01). A mean serum ferritin >/=100 ng/mL was present in approximately two thirds of the anemic and target hemoglobin patients. Approximately 60% of all children were treated with intravenous iron. The mean Kt/V values were lower for anemic patients (1.46 +/- 0.4 vs. 1.53 +/- 0.3, P < 0.05). Anemic patients were less likely to have a normal serum albumin (29% anemic vs. 52% target hemoglobin patients, P < 0.001).
Conclusion:
In the final multivariable regression model, dialyzing <6 months, a low albumin, and a mean TSAT <20% remained significant predictors of anemia in children.
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