Related Experiment Videos
Soluble P-selectin levels, P-selectin polymorphisms and cardiovascular disease
A M Carter1, K Anagnostopoulou, M W Mansfield
1Academic Unit of Molecular Vascular Medicine, Research School of Medicine, University of Leeds, Leeds, UK. medamc@medphysics.leeds.ac.uk
Journal of Thrombosis and Haemostasis : JTH
|August 13, 2003
Summary
Soluble P-selectin levels are higher in coronary artery disease patients. The Thr715Pro P-selectin gene polymorphism is linked to sP-selectin levels, especially in smokers.
Area of Science:
- Cardiovascular Genetics
- Molecular Biology
- Immunology
Background:
- P-selectin is a cell adhesion molecule crucial for leukocyte interactions.
- Gene polymorphisms in P-selectin have been identified.
- Understanding soluble P-selectin (sP-selectin) associations with CAD and its genetic factors is important.
Purpose of the Study:
- To investigate the relationship between soluble P-selectin levels, P-selectin gene polymorphisms, and coronary artery disease (CAD).
Main Methods:
- Studied 249 CAD patients and 252 healthy controls.
- Measured soluble P-selectin levels.
- Analyzed P-selectin gene polymorphisms, including Thr715Pro, -1817 T/C, -1969 G/A, and -2123 C/G.
- Assessed linkage disequilibrium between polymorphisms.
Main Results:
- Soluble P-selectin was significantly higher in CAD patients compared to controls.
- The Thr715Pro polymorphism showed a significant association with sP-selectin levels.
- A significant interaction between Thr715Pro polymorphism and smoking status was observed.
- No significant association was found between any P-selectin genotype and myocardial infarction or stenosis.
Conclusions:
- Plasma sP-selectin levels are elevated in CAD patients.
- The Thr715Pro P-selectin gene polymorphism is associated with plasma sP-selectin levels.
- Smoking modulates the association between Thr715Pro and sP-selectin, though the mechanism requires further investigation.