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Association between interleukin-18 gene polymorphism 105A/C and asthma.

S Higa1, T Hirano, M Mayumi

  • 1Department III of Internal Medicine, Osaka University Medical School, Osaka Department of Pediatrics, Fukui Medical University School of Medicine, Fukui, Japan.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|August 13, 2003
PubMed
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Genetic variations in the Interleukin-18 (IL-18) gene were investigated. A specific polymorphism, 105A/C, was found more frequently in asthma patients, suggesting a potential link to asthma development.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Allergy Research

Background:

  • Interleukin-18 (IL-18) exhibits dual roles in allergic responses.
  • Genetic variations within the IL-18 gene's coding regions have not been previously documented.

Purpose of the Study:

  • To identify genetic polymorphisms in the coding regions of the IL-18 gene.
  • To examine the association between identified IL-18 gene polymorphisms and asthma in a case-control study.

Main Methods:

  • Screening of IL-18 gene coding regions for polymorphisms using PCR-single-stranded conformation polymorphism.
  • Direct sequencing of PCR products to confirm polymorphisms.
  • Case-control analysis to assess the association between polymorphisms and asthma.

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Main Results:

  • A single polymorphism, 105A/C, was identified in the IL-18 coding region.
  • The 105A allele was significantly more prevalent in asthma patients compared to controls (OR=1.83, P<0.01).
  • Significant linkage disequilibrium was noted between the 105A/C and 5' flanking region (-137G/C) polymorphisms.

Conclusions:

  • The 105A/C polymorphism in the IL-18 gene is a potential risk factor for asthma.
  • This genetic variation may contribute to the pathogenesis of asthma.