[Anthelmintic Effect Of Oxantel And Oxantel/pyrantel Tablets Against Intestinal Nematode Infections]

Present trial was carried out to evaluate the anthelmintic efficacy of oxantel/pyrantel tablets against intestinal nematode infections, and to determine the efficacy of oxantel tablels against Trichuris infection. A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg. All stool examinations were done before the treatment and 3 weeks after the treatment. The cellophane thick smear (Kato's technique) and Stoll's dilution egg counting method were employed. The results of the trial were summarized as follows: 1. The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3% and 97% in trichuriasis, 100% each in ascariasis and ancylostomiasis. 2. The oxantel tablet treated group demonstrated a cure rate of 90.9% and an egg reduction rate of 96.3% in the treatment of Trichuris. 3. There were no detectable objective and subjective side effects in this trial. Both oxantel/pyrantel and oxantel pamoate tablets were readily accepted and well tolerated.