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Related Experiment Videos

Prostatic and peripheral blood selenium levels after oral supplementation.

T R J Gianduzzo1, E G Holmes, U Tinggi

  • 1Department of Surgery, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

The Journal of Urology
|August 13, 2003
PubMed
Summary

Oral selenium supplementation increases selenium levels in both the prostate and peripheral blood. However, blood selenium measurements are not a reliable indicator of prostate selenium content in men.

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Area of Science:

  • Nutritional Science
  • Oncology
  • Urology

Background:

  • Selenium is a dietary trace element with proposed chemopreventive properties against prostate cancer.
  • Epidemiological studies suggest an inverse relationship between blood selenium levels and prostate cancer incidence.
  • Limited research exists on selenium absorption specifically by the prostate gland.

Purpose of the Study:

  • To investigate the effect of oral selenium supplementation on selenium levels within the prostate and peripheral blood.
  • To determine if selenium supplementation alters prostate tissue and blood selenium concentrations.
  • To assess the correlation between blood and prostate selenium levels after supplementation.

Main Methods:

  • A prospective trial involving 51 men undergoing prostate surgery for benign prostatic hyperplasia.

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  • Participants were randomly assigned to a control group or a group receiving 200 microg of oral selenium daily for 1 month.
  • Selenium levels in peripheral blood and prostate tissue were measured using inductively coupled plasma mass spectrometry.

    • Main Results:

    • Oral selenium supplementation significantly increased erythrocyte (blood) selenium levels (p = 0.008).
    • Prostate tissue selenium levels were also significantly higher in the supplemented group compared to controls (p = 0.016).
    • A poor correlation was observed between erythrocyte and prostate selenium levels in both control and supplemented groups.

    Conclusions:

    • Oral selenium supplementation effectively raises selenium levels in both prostatic tissue and peripheral blood in men not deficient in selenium.
    • Peripheral blood selenium measurements are not a reliable indicator of prostatic selenium content.
    • Further research may explore selenium's role in prostate health and cancer prevention.