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Ovarian function in female patients with multibacillary leprosy
Khanna Neena1, A C Ammini, Manjula Singh
1Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi-110 029, India. akhanna@mantraonline.com
Summary
Multibacillary leprosy affects female reproductive health, causing irregular periods and infertility. Elevated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were observed in patients, indicating potential hormonal imbalances impacting fertility.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Infectious Diseases
Background:
- Leprosy, particularly the multibacillary form, can impact various physiological systems.
- Hormonal imbalances are implicated in reproductive dysfunction.
Purpose of the Study:
- To investigate the sex hormone profile (LH, FSH, prolactin) in women with multibacillary leprosy.
- To assess the relationship between leprosy, hormonal levels, and gynecological events, including menstrual function and fertility.
Main Methods:
- Study included 86 adult female patients with multibacillary leprosy.
- Hormone levels (LH, FSH, prolactin) were measured.
- Gynecological events such as menstrual regularity and fertility status were recorded.
Main Results:
- One-third of patients reported irregular periods.
- Mean LH and FSH levels were significantly higher in leprosy patients compared to controls.
- Among married women with irregular periods, 50% were infertile.
- Seven infertile patients exhibited markedly elevated FSH and LH levels, approaching castration levels.
Conclusions:
- Multibacillary leprosy is associated with significant hormonal disturbances affecting female reproductive health.
- Elevated LH and FSH levels in leprosy patients correlate with menstrual irregularities and infertility.
- Leprosy-induced hormonal changes may lead to premature ovarian insufficiency or castration-like effects.
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