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Updated: Jul 21, 2026

Production of Transgenic Xenopus laevis by Restriction Enzyme Mediated Integration and Nuclear Transplantation
Published on: August 21, 2010
Nuclear replacement strategies
H Claude Sagi1, Q B Bao, Hansen A Yuan
1Division of Orthopedic Surgery, Department of Surgery, UCSF-Fresno Medical Education Program, University Medical Center, Department of Surgery/4th Floor, 445 South Cedar Avenue, Fresno, CA 93702, USA. eversosaggy@cs.com
Abstract:
Although still a technology in its infancy, nuclear replacement promises a potential alternative to arthrodesis for patients with discogenic back pain. It is ideally suited to those patients presenting early in the degenerative cascade with minimal to no arthritic changes or disc collapse. The physical nature of the implants seeks to restore the visco-elastic, biomechanical, and fluid characteristics of the natural disc, thus reducing pain while maintaining motion and function.
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