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Updated: Aug 8, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
[Application of mass spectrometry in the proteome research]
Jianjun Liu1, Zhixiong Zhuang, Pingjian Deng
1Department of Microbiology Test, Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China.
Abstract:
Electrospray ionization(ESI) and matrix-assisted laser desorption ionization(MALDI) are two kinds of newly-developed mass spectrometry techniques. The application of mass spectrometry is described in the proteome research such as MS charting, determination of molecular weight, peptide mass fingerprinting(PMF) and peptide sequence validation. The advantages of mass spectrometry are sensitive, accurate, rapid, high-throughput and automated. They have been proved a powerful technique and can be used as an important method for proteome research.
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