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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
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[Research progress on oxidative stress and apoptosis]

Qilong Chu1, Kedi Yang, Aiguo Wang

  • 1School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|August 14, 2003
PubMed

Insights

Oxidative stress, an imbalance of reactive oxygen species (ROS), can trigger programmed cell death (apoptosis). This review covers key mechanisms linking ROS to apoptosis, including NF-κB activation and DNA damage.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Context:

  • Oxidative stress is implicated in numerous diseases.
  • Understanding the link between oxidative stress and apoptosis is crucial for therapeutic development.

Purpose:

  • To review the current understanding of how oxidative stress induces apoptosis.
  • To summarize the molecular mechanisms involved in ROS-mediated apoptosis.

Summary:

  • Reactive oxygen species (ROS) can induce apoptosis through several pathways.
  • Mechanisms include activation of nuclear factor-kappa B (NF-κB), mitochondrial dysfunction, DNA damage leading to P53 activation, and activation of the stress-activated protein kinase (SAPK) pathway.

Impact:

  • Provides a consolidated overview of oxidative stress and apoptosis research.
  • Highlights key molecular players and pathways for potential therapeutic targeting.

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