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[Research progress on oxidative stress and apoptosis].
Qilong Chu1, Kedi Yang, Aiguo Wang
1School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wei Sheng Yan Jiu = Journal of Hygiene Research
|August 14, 2003
Summary
Oxidative stress, an imbalance of reactive oxygen species (ROS), can trigger programmed cell death (apoptosis). This review covers key mechanisms linking ROS to apoptosis, including NF-κB activation and DNA damage.
Area of Science:
- Biochemistry
- Cell Biology
- Molecular Biology
Context:
- Oxidative stress is implicated in numerous diseases.
- Understanding the link between oxidative stress and apoptosis is crucial for therapeutic development.
Purpose:
- To review the current understanding of how oxidative stress induces apoptosis.
- To summarize the molecular mechanisms involved in ROS-mediated apoptosis.
Summary:
- Reactive oxygen species (ROS) can induce apoptosis through several pathways.
- Mechanisms include activation of nuclear factor-kappa B (NF-κB), mitochondrial dysfunction, DNA damage leading to P53 activation, and activation of the stress-activated protein kinase (SAPK) pathway.
Impact:
- Provides a consolidated overview of oxidative stress and apoptosis research.
- Highlights key molecular players and pathways for potential therapeutic targeting.