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Related Experiment Videos

Do unliganded thyroid hormone receptors have physiological functions?

O Chassande1

  • 1Biomatériaux et Réparation Tissulaire, INSERM U 577, Université de Bordeaux 2, Zone Nord, Batiment 4A, 2ème étage, 146 rue Léo Saignat, 33076 Bordeaux, France. Olivier.Chassande@bordeaux.inserm.fr

Journal of Molecular Endocrinology
|August 14, 2003
PubMed
Summary
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Thyroid hormone receptors (TRs) exhibit intrinsic activity in their unliganded state (apoTRs) in vivo, influencing gene transcription during development and in adults. While not essential for embryonic development, apoTRs enhance transcriptional responses to thyroid hormone variations.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Developmental Biology

Background:

  • Thyroid hormone (TH) is crucial for vertebrate development and adult homeostasis.
  • TH exerts its functions via nuclear receptors (TRs) that regulate gene transcription.
  • The in vivo activity and physiological significance of unliganded TRs (apoTRs) remain unclear.

Purpose of the Study:

  • To investigate the in vivo activity and physiological role of unliganded thyroid hormone receptors (apoTRs).
  • To determine the significance of apoTRs during vertebrate development and in adult homeostasis.

Main Methods:

  • Analysis of experimental hypothyroidism and thyrotoxicosis in wild-type and TR knockout mice.
  • Assessment of apoTR activity, particularly TRalpha1, during embryonic and post-natal development.

Related Experiment Videos

  • Evaluation of apoTR contribution to transcriptional regulation in various tissues.

    • Main Results:

    • Data from wild-type and TR knockout mice support intrinsic apoTR activity in multiple tissues.
    • ApoTRs, especially TRalpha1, are prominent during early development but not essential for embryonic development.
    • The absence of TRs did not lead to severe embryonic or fetal developmental defects.
    • ApoTRs appear to broaden the scope of transcriptional responses to T3 variations in both developmental and adult stages.

    Conclusions:

    • Unliganded thyroid hormone receptors (apoTRs) possess intrinsic in vivo activity.
    • ApoTRs play a modulatory role, enhancing transcriptional responses rather than being fundamentally required for development.
    • TRalpha1 is important during early development but its absence does not cause severe defects.