Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CpG islands in human X-inactivation.

X Ke1, A Collins

  • 1Human Genetics, Duthie Building (808), University of Southampton, Tremona Road, Southampton SO16 6YD, UK. xiayi@well.ox.ac.uk

Annals of Human Genetics
|August 14, 2003
PubMed
Summary

Genes escaping X-inactivation have fewer CpG islands, suggesting these DNA regions are crucial for X-inactivation regulation. This finding challenges the role of LINE repeat elements in this process.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Klinefelter syndrome in a Holstein-Friesian bull: a case report.

Irish veterinary journal·2026
Same author

Design and evaluation of a custom circulating tumour DNA assay to detect endometrial cancer recurrence.

NPJ precision oncology·2026
Same author

Mixed laterally spreading tumour and neuroendocrine tumour in the rectum: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2025
Same author

Anisotropic superconductivity in the quasi-one-dimensional superconductor V<sub>2</sub>Ga<sub>5</sub>.

Scientific reports·2025
Same author

[Analysis of influencing factors on postoperative olfactory function in patients with chronic rhinosinusitis with nasal polyps].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same author

Placement, management and complications associated with peripheral intravenous catheter use in UK small animal practice.

The Journal of small animal practice·2024

Area of Science:

  • Genetics
  • Epigenetics
  • Genomics

Background:

  • X-inactivation is a crucial process in female mammals, silencing one X chromosome.
  • The regulatory mechanisms of genes escaping X-inactivation are not fully understood.
  • Previous hypotheses suggested repetitive elements might influence X-inactivation escape.

Purpose of the Study:

  • To investigate sequence features of genes escaping X-inactivation.
  • To compare repetitive elements and CpG islands in X-inactivation escape genes versus inactivated genes.
  • To determine factors contributing to genes escaping X-inactivation.

Main Methods:

  • Sequence comparison analyses of genes escaping X-inactivation, subject to X-inactivation, and random autosomal genes.
  • Investigation of coding and flanking sequences (1kb-100kb) for repetitive elements (LINE-L1, SINE MIR) and CpG islands.
  • Statistical analysis to identify significant differences.

Main Results:

  • No significant difference in LINE-L1 elements between escaping and inactivated genes.
  • Significantly reduced numbers of CpG islands and SINE MIR elements in genes escaping X-inactivation.
  • Genes escaping X-inactivation showed fewer CpG islands, especially in the 2kb upstream region.

Conclusions:

  • Lack of LINE repeat elements is unlikely to be a key factor for X-inactivation escape.
  • CpG islands may play a role in maintaining X-inactivation by providing methylation targets.
  • Reduced CpG islands are a significant characteristic of genes escaping X-inactivation regulation.

Related Experiment Videos