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Related Experiment Videos

Testosterone and atherosclerosis.

Arnold von Eckardstein1, Fredrick C W Wu

  • 1Institute of Clinical Chemistry, University Hospital of Zurich, Raemistrasse 100, CH-8091, Zurich, Switzerland. arnold.voneckardstein@ikc.usz.ch

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|August 14, 2003
PubMed
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The role of androgens in cardiovascular disease risk is complex. While associated with risks, testosterone

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Syndrome

Background:

  • Hypoandrogenemia and hyperandrogenemia are linked to coronary artery disease (CAD) risk.
  • Associated factors include obesity, insulin resistance, and dyslipidemia.
  • Gender differences and confounders complicate the role of endogenous androgens in atherosclerosis.

Purpose of the Study:

  • To clarify the precise role of endogenous androgens in atherosclerosis.
  • To evaluate the cardiovascular effects of exogenous androgens.
  • To assess the impact of testosterone on cardiovascular risk factors and disease.

Main Methods:

  • Review of existing literature on androgen effects on cardiovascular risk factors.
  • Analysis of studies on exogenous androgen administration in men and women.

Related Experiment Videos

  • Examination of testosterone's influence on macrophage function and cholesterol transport.

    • Main Results:

    • Exogenous androgens show mixed effects: decreasing HDL-C and PAI-1 (deleterious), but also reducing visceral fat and improving insulin sensitivity (beneficial).
    • Short-term testosterone use may improve angina and myocardial ischemia.
    • Animal studies generally show neutral or beneficial effects of testosterone on atherosclerosis development.

    Conclusions:

    • The overall effect of testosterone on cardiovascular disease risk is difficult to ascertain due to its wide-ranging in vivo effects.
    • It is premature to assume clinical benefits from manipulating sex hormones for CAD.
    • Therapeutic testosterone use in men need not be restricted by cardiovascular concerns.