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Skeletal requirements for optimal growth hormone replacement in the transitional years
Annice Mukherjee1, Andrea F Attanasio, Stephen M Shalet
1Department of Endocrinology, Christie Hospital, Wilmslow Road, Withington, Manchester, UK. stephen.m.shalet@man.ac.uk
Summary
Growth hormone (GH) impacts bone health beyond linear growth. Childhood-onset growth hormone deficiency (CO-GHD) affects bone mineral accretion, influencing peak bone mass and long-term skeletal health.
Area of Science:
- Endocrinology
- Bone Biology
- Pediatrics
Background:
- Growth hormone (GH) is crucial for linear growth during childhood and adolescence.
- GH also plays a significant role in bone remodeling and maintaining skeletal homeostasis.
- Childhood-onset growth hormone deficiency (CO-GHD) can impact bone development.
Purpose of the Study:
- To review the influence of CO-GHD on bone mineral accretion.
- To evaluate factors affecting peak bone mass achievement.
- To discuss the implications for skeletal health in later life.
Main Methods:
- Literature review focusing on GH, CO-GHD, and bone health.
- Analysis of methods for assessing bone mineral density (BMD).
- Evaluation of factors influencing peak bone mass.
Main Results:
- CO-GHD negatively affects bone mineral accretion.
- Limitations exist in current BMD assessment methods.
- Several factors influence the achievement of peak bone mass.
Conclusions:
- Understanding CO-GHD's impact on bone is critical.
- Optimizing peak bone mass is essential for lifelong skeletal health.
- Further research into BMD assessment and influencing factors is warranted.