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Updated: Sep 20, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Usefulness and safety of bepridil in converting persistent atrial fibrillation to sinus rhythm
Akira Fujiki1, Takayuki Tsuneda, Masataka Sugao
1The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. fujiki@ms.toyama-u.ac.jp
Abstract:
The aim of this study was to investigate the efficacy and safety of bepridil (a multichannel blocker including several potassium channels) for conversion of long-lasting atrial fibrillation (AF). Bepridil restored sinus rhythm alone or in combination with aprindine in 69% of 32 patients with persistent AF lasting > or = 3 months. The time to conversion after starting bepridil was 30 +/- 12 days. An increase in fibrillation cycle length with bepridil was greater in responders (31 +/- 10%), but an increase in QTc did not differ between responders and nonresponders. Bepridil is effective and safe for terminating long-lasting persistent AF.
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