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Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry
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K+ channels and T-cell synapses: the molecular background for efficient immunomodulation is shaping up

János Matkó1

  • 1Department of Immunology, Eötvös Lorand University, Pázmány P. sétány 1/C, 1117 Budapest, Hungary. matko@cerebrus.elte.hu

Trends in Pharmacological Sciences
|August 14, 2003
PubMed

Diverse K(+) channels exhibit differential expression and function in human lymphocytes. Voltage-gated and Ca(2+)-activated K(+) channels have a significant impact on both T-cell activation and the overall immune response. A recent study on the plasma membrane organization of Kv1.3 K(+) channels in human T cells provides new insights into the immunoregulatory functions of K(+) channels, which might result in new and improved immune suppression protocols targeted to ion channels and/or T-cell signaling and accessory molecules.

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