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Updated: Aug 4, 2026
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An Automated Method to Perform The In Vitro Micronucleus Assay using Multispectral Imaging Flow Cytometry
Published on: May 13, 2019
Micronuclei to detect in vivo chemotherapy damage in a p53 mutated solid tumour
G Driessens1, L Harsan, B Robaye
1Interdisciplinary Research Institute (IRIBHM), Faculty of Medicine, Université Libre de Bruxelles, 1070 Brussels, Belgium.
British Journal of Cancer
|August 14, 2003
Abstract:
Apoptosis induction and micronuclei formation were compared following cytotoxic treatments in two rat glioma differing in p53 integrity. In vitro, micronuclei emergence but not apoptosis was linked to the p53 mutated status. In vivo, micronuclei assays were more sensitive to evaluate DNA damage induced by chemotherapy in a p53-mutated solid tumour.
