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A triterpene ozonide from Senecio selloi.
Gerhard Rücker1, Detlef Manns, Eloir P Schenkel
1Pharmazeutisches Institut der Universität Bonn, Kreuzbergweg 26, D-53115 Bonn, Germany. pharmchem@uni-bonn.de
Archiv Der Pharmazie
|August 14, 2003
Summary
A novel triterpene ozonide was isolated from Senecio selloi. This compound, ozonide 1, showed no antiplasmodial activity, unlike related natural peroxides.
Area of Science:
- Phytochemistry
- Organic Chemistry
- Medicinal Chemistry
Background:
- Senecio selloi (Asteraceae) is a plant source of bioactive compounds.
- Natural peroxides often exhibit significant biological activities, including antiplasmodial effects.
Purpose of the Study:
- To isolate and characterize new compounds from Senecio selloi.
- To investigate the antiplasmodial activity of the novel ozonide.
Main Methods:
- Isolation of compounds from dried and fresh aerial parts of Senecio selloi.
- Structure elucidation using Nuclear Magnetic Resonance (NMR) experiments, including Heteronuclear Multiple-Quantum Coherence (HMQC) and Heteronuclear Multiple-Bond Correlation (HMBC) techniques.
- Chemical synthesis of the ozonide from a precursor.
Main Results:
- A new triterpene ozonide, designated as ozonide 1, was successfully isolated.
- The structure of ozonide 1 was confirmed through comprehensive NMR analysis and chemical synthesis.
- Ozonide 1 did not exhibit any antiplasmodial activity in vitro.
Conclusions:
- The study reports the isolation and structural characterization of a novel triterpene ozonide from Senecio selloi.
- The absence of antiplasmodial activity in ozonide 1 differentiates it from other natural peroxide compounds.