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Decrease of lactase activity in the small intestine of jejunum-bypassed rats.

H Shinohara1, T Goda, S Takase

  • 1Department of Education, Miyazaki University, Japan.

Journal of Nutritional Science and Vitaminology
|August 1, 1992
PubMed
Summary
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Jejunum bypass surgery in rats reduced lactase activity in the remaining small intestine. This bypass operation did not enhance lactase levels in the ileum to compensate for the lost jejunum function.

Area of Science:

  • Gastroenterology
  • Physiology
  • Biochemistry

Background:

  • The jejunum plays a crucial role in nutrient digestion and absorption.
  • Understanding the impact of surgical alterations on intestinal enzyme activity is vital for managing digestive disorders.

Purpose of the Study:

  • To investigate the effect of jejunum-bypass surgery on lactase activity in the rat small intestine.
  • To determine if the ileum compensates for the loss of jejunal function regarding lactase levels.

Main Methods:

  • Rats underwent jejunum-bypass or sham operations.
  • Post-operation, animals were fed specific diets.
  • Lactase and sucrase activity, along with protein and DNA content, were measured in intestinal segments via electroimmunoassay and biochemical assays.

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Main Results:

  • Jejunum-bypass led to ileal hyperplasia, indicated by increased protein and DNA.
  • Specific lactase activity significantly decreased in the ileum and jejunum of bypassed rats compared to controls.
  • Sucrase activity increased in the ileum of bypassed rats.
  • Reduced lactase levels were observed even in jejunal segments deprived of luminal nutrition, suggesting hormonal involvement.

Conclusions:

  • Jejunum-bypass surgery reduces overall lactase activity in the rat small intestine.
  • The ileum does not compensate for the loss of jejunal digestive-absorptive surface by increasing lactase activity.
  • Hormonal factors may contribute to the observed decrease in lactase activity following jejunum-bypass.