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Updated: Aug 14, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Rosai-Dorfman disease (sinus histiocytosis with multiple lymphadenopathy]
A Ferrer Rodríguez1, M A Agut Fuster, A Jiménez
1Servicio de ORL, Hospital Francesc de Borja, Gandía, Valencia.
Abstract:
The entity known as sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease, is an uncommon benign proliferation of hematopoietic and fibrous tissue is that often present in the head and neck region. Its initial manifestations include bilateral cervical adenopathies, and in a high percentage it has an extranodal affectation. Its cause is unknown and it usually resolves satisfactorily. We present a case and we revise the literature.
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