Related Experiment Video
Updated: Sep 20, 2026

A Microfluidic System for Modeling Endothelial Dysfunction under Combined Physiological Pulsatile Shear Stress and Oscillatory Hyperglycemia
Published on: May 12, 2026
Comparison of different risk factors that result in endothelial damage leading to diabetic microangiopathy
Seyit Mehmet Kayacan1, Rümeyza Kazancioğlu, Hüseyin Oflaz
1Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul, Turkey. kayacansm@yahoo.com
Abstract:
In this study, the effect of different risk factors (hyperglycemia, hypertension, hyperlipidemia, hyperuricemia) on endothelial damage was evaluated in 61 (two of them were type 1; the other patients were type 2) diabetic patients. von Willebrand factor antigen was used as the marker of the endothelial damage. Although there was no significant decrease (P > 0.05) in von Willebrand factor level after regulation of nonregulated diabetes, a significant decrease was determined in nonregulated and hypertensive diabetic patients after improvement of risk factors (P < 0.05). As a result, nonregulated diabetes alone has less effect than nonregulated diabetes plus other risk factors (particularly hypertension) on diabetic angiopathy.
Related Concept Videos
Diabetic Retinopathy
Diabetic Nephropathy
Coronary Artery Disease I: Introduction
Complications of Diabetes Mellitus
Diabetic Foot Ulcer
Peripheral Artery Disease I: Introduction
