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Related Experiment Videos

Aging, blood pressure and mortality.

C J Bulpitt1, A E Fletcher

  • 1Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|December 1, 1992
PubMed
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Blood pressure control in the Hypertension in the Very Elderly Trial (HYVET).

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Blood pressure and mortality show a complex relationship in older adults. While high blood pressure is linked to mortality in younger elderly individuals, very elderly individuals with high blood pressure may live longer.

Area of Science:

  • Gerontology
  • Cardiovascular Health
  • Epidemiology

Background:

  • Population studies reveal a shifting relationship between blood pressure and mortality with advanced age.
  • A positive association between blood pressure and mortality observed in younger elderly individuals (60-69 years) weakens with increasing age.
  • Over 85 years, a negative relationship emerges, where hypertension may be associated with increased longevity.

Purpose of the Study:

  • To analyze the association between blood pressure and mortality across different age groups in the elderly.
  • To evaluate the implications of these findings for antihypertensive treatment in very elderly populations.
  • To identify the need for further research, specifically randomized controlled trials, in this demographic.

Main Methods:

Related Experiment Videos

  • Systematic review of population studies examining blood pressure and mortality in the elderly.
  • Analysis of trends in the blood pressure-mortality relationship across age strata (60-69, 75+, 85+).
  • Review of existing clinical trial data on antihypertensive treatment efficacy in the elderly.

    • Main Results:

    • The mortality risk associated with elevated blood pressure diminishes with age, becoming negative (protective) over 85 years.
    • Very elderly individuals with low blood pressure may have poorer prognoses due to underlying conditions like cardiac, respiratory, or neoplastic diseases.
    • Current clinical trial evidence is insufficient to determine the benefits of treating hypertension in individuals over 80 years.

    Conclusions:

    • The complex, age-dependent relationship between blood pressure and mortality necessitates cautious interpretation of hypertension management in the very elderly.
    • Lower blood pressure in the very elderly might indicate underlying comorbidities, not necessarily a healthier state.
    • A robust, randomly allocated controlled trial is essential to guide antihypertensive treatment decisions in individuals over 80 years.