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Related Experiment Videos

Peripheral third cranial nerve enhancement in multiple sclerosis.

M Tariq Bhatti1, Ilona M Schmalfuss, Lorna S Williams

  • 1Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA.

AJNR. American Journal of Neuroradiology
|August 15, 2003
PubMed
Summary

Multiple sclerosis (MS) rarely causes cranial nerve III dysfunction. A case study shows MS may involve peripheral nerves, evidenced by cranial nerve enhancement on MRI, suggesting a broader disease process.

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Area of Science:

  • Neuroscience
  • Neurology
  • Ophthalmology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease primarily affecting the central nervous system.
  • Cranial nerve III (oculomotor nerve) dysfunction is an infrequent manifestation of MS.
  • Previous reports documented midbrain lesions in MS patients with cranial nerve III palsy.

Observation:

  • This study details a young woman with MS presenting with isolated, painful complete left cranial nerve III palsy.
  • The patient's initial magnetic resonance (MR) imaging revealed isolated enhancement of the cisternal portion of the cranial nerve III.
  • This finding suggests potential peripheral nervous system involvement in MS.

Findings:

  • The case highlights an unusual presentation of MS involving cranial nerve III.

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  • MR imaging demonstrated enhancement specifically in the cisternal segment of the oculomotor nerve.
  • This indicates that MS pathology may extend to the peripheral components of cranial nerves.

    • Implications:

    • Peripheral nervous system involvement should be considered in the spectrum of MS manifestations.
    • Oculomotor nerve enhancement on MR imaging may serve as an early indicator of MS progression.
    • Understanding these atypical presentations can improve diagnostic accuracy and patient management in MS.