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Related Experiment Videos

Amphetamines for improving recovery after stroke.

L Martinsson1, N G Wahlgren, H-G Hårdemark

  • 1Department of Neurology R2:03, Stroke Research Unit, Karolinska Hospital, Stockholm, SWEDEN, 171 76.

The Cochrane Database of Systematic Reviews
|August 15, 2003
PubMed
Summary
This summary is machine-generated.

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Amphetamine treatment after stroke shows potential for improving motor and language function, but more research is needed to confirm benefits and assess risks. Current studies are limited by small sample sizes and potential biases.

Area of Science:

  • Neuroscience
  • Clinical Neurology
  • Pharmacology

Background:

  • Animal studies suggest amphetamines aid recovery from focal cerebral ischemia.
  • Translating this to human stroke recovery could significantly impact patient outcomes.

Purpose of the Study:

  • To systematically review the effects of amphetamine treatment in patients following a stroke.

Main Methods:

  • Searched multiple databases (Cochrane Stroke Group, MEDLINE, EMBASE, Science Citation Index) up to 2002.
  • Included randomized controlled trials comparing amphetamine with placebo.
  • Two independent reviewers assessed trial quality and extracted data.

Main Results:

  • Seven studies with 172 patients were analyzed.

Related Experiment Videos

  • No significant reduction in death or dependence was observed.
  • Evidence suggests improved motor function (Fugl-Meyer scale) and language function (Porch Index).

    • Conclusions:

    • Current evidence is insufficient to definitively conclude on amphetamine's efficacy for stroke recovery.
    • Observed functional improvements and a trend towards increased mortality require further investigation due to potential biases.
    • Additional research is warranted to clarify the role of amphetamines in stroke rehabilitation.