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Related Experiment Videos

Interventions for herpes simplex virus epithelial keratitis.

K R Wilhelmus1

  • 1Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin Street, NC-205, Suite NC-304, Houston, TX 77030, USA.

The Cochrane Database of Systematic Reviews
|August 15, 2003
PubMed
Summary
This summary is machine-generated.

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Topical antiviral agents like vidarabine, trifluridine, and acyclovir effectively treat herpes simplex virus epithelial keratitis, with similar healing rates. Combining antivirals with debridement or interferon may accelerate healing.

Area of Science:

  • Ophthalmology
  • Virology
  • Pharmacology

Background:

  • Dendritic epithelial keratitis is a common ocular condition requiring effective treatment.
  • Numerous clinical trials have investigated various interventions for acute herpes simplex virus (HSV) epithelial keratitis.
  • A comprehensive systematic review of comparative studies was lacking.

Purpose of the Study:

  • To systematically review and compare the efficacy of different treatments for dendritic or geographic HSV epithelial keratitis.
  • To evaluate topical ophthalmic or oral antiviral agents, and physical or chemical debridement methods.

Main Methods:

  • A systematic search of multiple databases (CENTRAL, MEDLINE, EMBASE, LILACS, etc.) was conducted up to August 2002.
  • Included were comparative clinical trials assessing one- or two-week healing rates of antiviral agents or debridement.

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  • Data extraction and quality assessment were performed, comparing participant healing proportions at 7 and 14 days.

    • Main Results:

    • Data from 97 trials involving 5102 participants were analyzed.
    • Topical vidarabine, trifluridine, and acyclovir showed significantly higher one-week healing rates compared to idoxuridine.
    • No single antiviral agent among vidarabine, trifluridine, or acyclovir demonstrated superior efficacy; interferon showed benefit when combined with debridement or other antivirals.

    Conclusions:

    • Current antiviral agents for HSV epithelial keratitis are effective and largely comparable.
    • Combining nucleoside antivirals with debridement or interferon may enhance healing speed.
    • Future research should focus on statistically powerful trials assessing epithelial healing outcomes and considering lesion characteristics.