Jove
Visualize
Contact Us

Related Experiment Videos

Interventions for treating collagenous colitis.

N Chande1, J W D McDonald, J K MacDonald

  • 15-OF 12 LHSC-UC, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.

The Cochrane Database of Systematic Reviews
|August 15, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic review with meta-analysis: prevalence, risk factors and costs of aminosalicylate use in Crohn's disease.

Alimentary pharmacology & therapeutics·2018
Same author

Letter: predicting azathioprine-associated pancreatitis in IBD-phenotype or genotype? Authors' reply.

Alimentary pharmacology & therapeutics·2018
Same author

HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.

Alimentary pharmacology & therapeutics·2017
Same author

Systematic review with meta-analysis: placebo rates in induction and maintenance trials of Crohn's disease.

Alimentary pharmacology & therapeutics·2017
Same author

Genetic Predictors of Azathioprine Toxicity and Clinical Response in Patients with Inflammatory Bowel Disease.

Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique·2016
Same author

Reliability among central readers in the evaluation of endoscopic findings from patients with Crohn's disease.

Gut·2015
Same journal

Interventions to prevent or cease electronic cigarette use in children and adolescents.

The Cochrane database of systematic reviews·2026
Same journal

Drugs to improve anaemia, quality of life, and physical function in people with myelodysplastic syndromes (MDS).

The Cochrane database of systematic reviews·2026
Same journal

Interventions for smoking cessation in inpatient psychiatry settings.

The Cochrane database of systematic reviews·2026
Same journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same journal

Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.

The Cochrane database of systematic reviews·2026
Same journal

Views and experiences of weight management for people living with mobility‑limiting conditions, intellectual disabilities or severe mental illness: a qualitative evidence synthesis.

The Cochrane database of systematic reviews·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Budesonide is an effective treatment for collagenous colitis, significantly improving clinical and histological outcomes. Bismuth subsalicylate shows promise, but more research is needed for both therapies in long-term remission.

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Clinical Medicine

Background:

  • Collagenous colitis causes chronic diarrhea, with treatments lacking robust evidence.
  • This review aimed to identify therapies supported by randomized controlled trials.

Purpose of the Study:

  • Determine effective treatments for active collagenous colitis.
  • Evaluate evidence from randomized trials for collagenous colitis therapies.

Main Methods:

  • Systematic literature search of MEDLINE, PubMed, Cochrane databases (1970-2003).
  • Included randomized trials of collagenous colitis treatments.
  • Data extraction and analysis using chi-square tests and Peto odds ratios.

Main Results:

Related Experiment Videos

  • Budesonide (9 mg daily) demonstrated significant clinical and histological improvement (pooled OR 12.32, NNT=2).
  • Bismuth subsalicylate showed significant clinical and histological improvement in one trial (p=0.003).

    • Conclusions:

    • Budesonide is an effective treatment for collagenous colitis.
    • Bismuth subsalicylate shows potential, though evidence is less robust.
    • Further research is needed on the role of these therapies in inducing/maintaining remission.