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Hoxa10 and Hoxd10 coordinately regulate lumbar motor neuron patterning.

Amy W Lin1, Ellen M Carpenter

  • 1Mental Retardation Research Center, Department of Psychiatry, UCLA School of Medicine, Los Angeles, California 90024, USA.

Journal of Neurobiology
|August 15, 2003
PubMed
Summary

The paralogous Hox genes Hoxa10 and Hoxd10 are crucial for lumbar motor neuron development. Their combined inactivation disrupts motor neuron numbers, positioning, and identity, impacting spinal cord organization.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Hoxa10 and Hoxd10 are paralogous Hox genes with overlapping expression in the developing lumbar spinal cord.
  • Previous studies showed individual gene inactivation affects spinal nerve trajectory and motor neuron numbers.

Purpose of the Study:

  • To investigate the combined role of Hoxa10 and Hoxd10 in the organization and distribution of lumbar motor neurons.
  • To analyze the effects of double inactivation on motor neuron specification and spinal cord development.

Main Methods:

  • Analysis of Hoxa10/Hoxd10 double mutant mouse models.
  • Examination of lumbar motor neuron organization, distribution, and positional specificity.
  • Assessment of spinal cord vasculature and kidney development.

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Main Results:

  • Double mutants exhibit reduced numbers of lumbar motor neurons in medial and lateral motor columns.
  • The lumbar motor column shows a caudal shift in anteroposterior position and altered segmental distribution.
  • Positional specificity distinctions between motor neuron classes are disrupted, alongside abnormal vasculature and kidney development.

Conclusions:

  • Hoxa10 and Hoxd10 activity is essential for specifying the lumbar motor column's position.
  • These genes play a critical role in providing segmental specification and identity to lumbar motor neurons.
  • Disruption impacts spinal cord organization, vasculature, and associated organ development.