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Expression of class I MHC molecule, HSP70 and TAP in human hepatocellular carcinoma
Xiao-Ling Deng1, Wei Chen, Mei-Ying Cai
1Immunology Department, West China Medical Center of Sichuan University, Chengdu 610044, Sichuan Province, China.
Aim:
To demonstrate whether class I MHC molecule, transporter associated with antigen processing (TAP), and heat-shock proteion70 (HSP70) expressed in liver cancer cells before the design and construction of CTL vaccine against hepatocellular carcinoma (HCC).
Methods:
We studied 30 HCC specimens by labeled streptavidin biotin (LSAB) method of immunohistochemistry.
Results:
The results showed that the majority of HCC cells investigated naturally expressed class I MHC and TAP, which were different from other tumor cells. Furthermore, we found that HSP70 expressed not only in cellular cytoplasm, but also on the cell surface in HCC.
Conclusion:
Our findings indicate that our understanding about immune escape mechanisms employed by HCC cells may be further improved. It is important to design and construct CTL vaccine against HCC.
