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Related Experiment Videos

Furazolidone-pethidine interaction in rabbits.

I B Eltayeb, O H Osman

    British Journal of Pharmacology
    |December 1, 1975
    PubMed
    Summary

    Furazolidone and pethidine interaction in rabbits caused fatal hyperpyrexia. This interaction, potentially mediated by 5-hydroxytryptamine, was prevented by certain drugs and exacerbated by DDT.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Microbiology

    Background:

    • Furazolidone is an antimicrobial agent.
    • Pethidine is an opioid analgesic.
    • Drug interactions can lead to severe adverse effects.

    Purpose of the Study:

    • To investigate the interaction between furazolidone and pethidine in rabbits.
    • To identify the mechanisms underlying this interaction.
    • To evaluate potential protective agents against the interaction.

    Main Methods:

    • Rabbits were pretreated with furazolidone orally.
    • Pethidine was administered intravenously.
    • Various agents (rho-chlorophenylalanine, chloropromazine, cyproheptadine, alpha-methyl-rho-tyrosine, 5-hydroxytryptophan, DDT, oxytetracycline) were used to assess their effects on the interaction.

    Main Results:

    • Furazolidone pretreatment potentiated pethidine's effects, leading to fatal hyperpyrexia.
    • rho-Chlorophenylalanine, chloropromazine, and cyproheptadine protected against the interaction.
    • 5-Hydroxytryptophan induced fatal hyperpyrexia in furazolidone-pretreated rabbits.
    • DDT accelerated the interaction, while oxytetracycline prevented it.

    Conclusions:

    • The furazolidone-pethidine interaction is likely mediated by enhanced 5-hydroxytryptamine activity in the central nervous system.
    • Furazolidone may be metabolized into a monoamine oxidase inhibitor by gut microflora.
    • Understanding this interaction is crucial for safe drug use.

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